Negative regulation of protein localization to membrane

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B4, ITGA4, and XAF1, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to membrane activity versus ATP8B4 in SARC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	ATP8B4 →	+0.736	+0.024	<.001	<.001	3	31
DLBC	ITGA4 →	+1.909	+0.076	<.001	.001	3	31
SCLC	XAF1 →	+1.530	+0.145	<.001	<.001	3	31
THYM	PTPRC →	+1.818	+0.050	<.001	<.001	3	31
CHOL	SLCO2B1 →	+1.644	+0.056	<.001	.002	3	30
SCLC	GBP5 →	+2.789	+0.146	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905476 vs ATP8B4 — SARC

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