Negative regulation of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRATD2, MAPK13, and CNKSR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRATD2 grouped by Negative regulation of protein localization to membrane-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LRATD2 →	+4.135	+0.460	<.001	<.001	3	6
BLOOD_Myeloma	MAPK13 →	+2.803	+0.343	.005	.001	3	6
LUNG_NSCLC_LUSC	CNKSR1 →	+2.047	+0.387	.003	.001	3	6
LUNG_NSCLC_LUAD	MMP15 →	+1.117	+0.380	.001	.007	3	5
LUNG_SCLC	TBC1D30 →	+1.574	+0.246	.008	.004	3	5
BONE	GLT8D1 →	-0.591	-0.415	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRATD2 by Negative regulation of protein localization to membrane activity — BONE

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