Regulation of mitochondrial ATP synthesis coupled electron transport

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial ATP synthesis coupled electron transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGBL1, ZNF404, and GOLGA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGBL1 grouped by Regulation of mitochondrial ATP synthesis coupled electron transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ITGBL1 →	+1.473	+0.147	.005	<.001	3	5
LUNG_NSCLC_LUSC	ZNF404 →	+1.887	+0.251	<.001	<.001	3	5
PANCREAS	GOLGA5 →	+0.643	+0.147	.004	.006	3	4
SOFT_TISSUE	CEND1 →	+3.034	+0.227	<.001	<.001	3	4
CNS	ZNF436 →	+0.769	+0.090	.005	.008	3	4
LUNG_NSCLC_LUSC	ATP8B3 →	+1.894	+0.222	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGBL1 by Regulation of mitochondrial ATP synthesis coupled electron transport activity — LUNG_NSCLC_LUAD

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