Regulation of mitochondrial ATP synthesis coupled electron transport

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial ATP synthesis coupled electron transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPF, LTA4H, and TMEM140, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial ATP synthesis coupled electron transport activity versus HNRNPF in LUNG_NSCLC_LUAD (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HNRNPF →	+0.583	+0.747	.001	.002	3	6
LIVER	LTA4H →	+0.863	+1.687	.009	.001	3	5
BLOOD_Lymphoma	TMEM140 →	-1.031	-1.172	.001	<.001	3	5
LIVER	TRIM37 →	+1.136	+1.775	.004	<.001	3	5
SKIN	CSTF2T →	+0.470	+0.738	.002	.004	3	5
BREAST	AXIN1 →	+0.730	+1.050	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905446 vs HNRNPF — LUNG_NSCLC_LUAD

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