Positive regulation of morphogenesis of an epithelium

Across TCGA cell cohorts, RNA activity of the Positive regulation of morphogenesis of an epithelium pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH3, TLR4, and ZEB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of morphogenesis of an epithelium activity versus CDH3 in URINARY_TRACT (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDH3 →	+5.162	+1.697	.008	.001	3	6
CNS	TLR4 →	+2.603	+0.973	.002	.008	3	6
PANCREAS	ZEB1 →	-1.769	-1.186	<.001	.009	3	6
BONE	METRNL →	+3.158	+2.032	<.001	<.001	3	6
PANCREAS	DAPP1 →	+3.316	+1.418	<.001	.002	3	6
STOMACH	RHOD →	+2.765	+1.071	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905332 vs CDH3 — URINARY_TRACT

Explore this scatter interactively →