Telomerase holoenzyme complex assembly

Across TCGA cell cohorts, RNA activity of the Telomerase holoenzyme complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NABP2, DEPTOR, and ATP5F1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomerase holoenzyme complex assembly activity versus NABP2 in BLOOD_Lymphoma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NABP2 →	+0.745	+0.109	.002	.001	3	7
SKIN	DEPTOR →	+0.812	+0.144	.008	.001	3	6
UPPER_AERODIGESTIVE_TRACT	ATP5F1B →	+1.045	+0.223	.001	.002	3	5
STOMACH	NR4A1 →	+2.278	+0.281	.008	.004	3	5
UPPER_AERODIGESTIVE_TRACT	WDR75 →	+0.818	+0.247	.002	.002	3	5
UPPER_AERODIGESTIVE_TRACT	PTGES3 →	+1.168	+0.224	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905323 vs NABP2 — BLOOD_Lymphoma

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