"Regulation of retrograde transport, endosome to Golgi"

Across TCGA patient cohorts, RNA activity of the "Regulation of retrograde transport, endosome to Golgi" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK8_S451, RNF213, and RAB29, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of retrograde transport, endosome to Golgi" activity versus DOCK8_S451 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK8_S451 →	+0.882	+0.098	<.001	<.001	3	7
UCEC	RNF213 →	+0.432	+0.083	<.001	<.001	3	7
BRCA	RAB29 →	+0.502	+0.054	<.001	<.001	3	7
BRCA	AUP1 →	+0.349	+0.037	.004	.008	2	6
HNSC	ROGDI →	+0.207	+0.058	.001	.002	3	5
LSCC	STK10 →	+0.258	+0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905279 vs DOCK8_S451 — LSCC

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