"Regulation of retrograde transport, endosome to Golgi"

Across TCGA patient cohorts, RNA activity of the "Regulation of retrograde transport, endosome to Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCSAP, TTF2, and VDAC2P5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of retrograde transport, endosome to Golgi" activity versus CCSAP in GBM (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCSAP →	-0.534	-0.091	.002	.006	3	4
LSCC	TTF2 →	-0.412	-0.347	.001	.003	3	4
LSCC	VDAC2P5 →	-0.336	-0.362	.001	.009	3	4
BRCA	FBXO41 →	-0.504	-0.682	.004	<.001	3	3
LSCC	PRRT3-AS1 →	-0.584	-0.487	.001	.003	3	3
PDAC	ASNS →	-0.386	-0.150	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905279 vs CCSAP — GBM

Explore this scatter interactively →