"Regulation of retrograde transport, endosome to Golgi"

Across TCGA cell cohorts, RNA activity of the "Regulation of retrograde transport, endosome to Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP21, MFSD3, and CTTNBP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP21 grouped by "Regulation of retrograde transport, endosome to Golgi"-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ARHGAP21 →	-0.948	-0.470	<.001	<.001	3	3
CNS	MFSD3 →	+1.123	+1.123	<.001	.001	3	3
LIVER	CTTNBP2 →	-1.259	-0.999	<.001	.004	3	3
CNS	HCN2 →	-1.311	-0.759	.001	.001	3	3
LUNG_SCLC	COQ6 →	+0.456	+0.289	.007	.009	3	3
LUNG_SCLC	GLTP →	+0.544	+0.366	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP21 by "Regulation of retrograde transport, endosome to Golgi" activity — OESOPHAGUS

Explore this box plot interactively →