"Regulation of retrograde transport, endosome to Golgi"

Across TCGA cell cohorts, RNA activity of the "Regulation of retrograde transport, endosome to Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB29, DOP1B, and ATP9A, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of retrograde transport, endosome to Golgi" activity versus RAB29 in BLOOD_Myeloma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RAB29 →	+1.471	+0.167	.001	.004	1	14
BONE	DOP1B →	+1.738	+0.170	<.001	.002	3	11
PANCREAS	ATP9A →	+1.793	+0.131	<.001	<.001	3	11
LARGE_INTESTINE	MON2 →	+0.787	+0.061	.002	.007	3	10
PANCREAS	PPP1R12B →	+0.722	+0.115	<.001	<.001	3	9
OESOPHAGUS	SPTLC2 →	+1.080	+0.077	.003	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905279 vs RAB29 — BLOOD_Myeloma

Explore this scatter interactively →