"Regulation of retrograde transport, endosome to Golgi"

Across TCGA cell cohorts, RNA activity of the "Regulation of retrograde transport, endosome to Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYB, ARHGEF16, and FAM117B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of retrograde transport, endosome to Golgi" activity versus MYB in LARGE_INTESTINE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYB →	+2.461	+0.951	.001	.002	3	5
LIVER	ARHGEF16 →	+3.126	+1.277	.008	.002	3	5
KIDNEY	FAM117B →	+1.068	+1.355	.001	.001	2	6
LARGE_INTESTINE	PDE3B →	+1.495	+0.990	<.001	<.001	3	5
STOMACH	AKR7A3 →	+3.398	+1.341	<.001	<.001	3	5
LIVER	FBRSL1 →	+1.792	+1.560	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905279 vs MYB — LARGE_INTESTINE

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