Positive regulation of epithelial tube formation

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial tube formation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYTL3_S243, PDK3, and MDM1_S601, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial tube formation activity versus SYTL3_S243 in LUAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SYTL3_S243 →	+0.837	+0.070	<.001	<.001	3	4
OV	PDK3 →	+0.432	+0.059	.001	.001	3	4
BRCA	MDM1_S601 →	+0.702	+0.072	<.001	<.001	3	4
LUAD	SIX1_S204 →	+1.617	+0.123	.001	<.001	3	4
HNSC	PCIF1_S116 →	+0.278	+0.069	.002	.002	2	5
PDAC	CGN_S338 →	+0.452	+0.066	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905278 vs SYTL3_S243 — LUAD

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