Positive regulation of epithelial tube formation

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial tube formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC2, SLIT2, and DST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial tube formation activity versus NFATC2 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NFATC2 →	+0.588	+0.402	.002	.003	3	5
UCEC	SLIT2 →	+1.260	+0.613	.002	.004	3	4
UCEC	DST →	+0.660	+0.484	.002	.002	3	4
UCEC	FREM1 →	+1.002	+0.573	<.001	.003	3	4
UCEC	SUMO2P6 →	-0.944	-0.796	.002	<.001	3	4
UCEC	EPB41L2 →	+0.589	+0.456	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905278 vs NFATC2 — BRCA

Explore this scatter interactively →