Positive regulation of epithelial tube formation

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial tube formation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDNF, GATA3, and SIX4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDNF grouped by Positive regulation of epithelial tube formation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GDNF →	-0.438	-1.223	<.001	<.001	3	9
BREAST	GATA3 →	-0.697	-0.495	<.001	<.001	3	7
KIDNEY	SIX4 →	-0.190	-1.091	.001	.007	1	7
BLOOD_Myeloma	SIX1 →	-0.297	-1.448	.001	.002	3	4
BLOOD_Lymphoma	ACTG2 →	-0.772	-2.170	.006	<.001	3	4
BLOOD_Lymphoma	ZNF431 →	-0.275	-2.135	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDNF by Positive regulation of epithelial tube formation activity — SKIN

Explore this box plot interactively →