Positive regulation of epithelial tube formation

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial tube formation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EME2, CCDC120, and RNF208, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EME2 grouped by Positive regulation of epithelial tube formation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EME2 →	+1.078	+1.218	.001	.001	3	5
BREAST	CCDC120 →	+1.416	+0.620	<.001	.001	3	4
BONE	RNF208 →	+2.660	+1.755	<.001	<.001	2	5
BONE	RAB32 →	-4.165	-1.843	<.001	<.001	2	5
BLOOD_Myeloma	MDM2 →	+1.483	+1.640	.007	<.001	3	4
CNS	PCBP2 →	+0.549	+1.362	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EME2 by Positive regulation of epithelial tube formation activity — LIVER

Explore this box plot interactively →