Positive regulation of epithelial tube formation

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial tube formation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUS1, PRORP, and HAGHL, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial tube formation activity versus PUS1 in BREAST (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PUS1 →	+0.806	+1.609	.001	<.001	3	2
BREAST	PRORP →	+0.973	+1.609	<.001	<.001	3	1
BREAST	HAGHL →	+2.322	+1.609	<.001	<.001	3	1
BREAST	EEF2K →	+0.642	+1.609	<.001	<.001	3	1
BREAST	SLC9A3R1 →	+2.867	+1.609	.008	<.001	3	1
BREAST	BST1 →	-1.839	-1.904	.006	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905278 vs PUS1 — BREAST

Explore this scatter interactively →