Regulation of modification of synaptic structure

Across TCGA cell cohorts, RNA activity of the Regulation of modification of synaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH2B3, SOCS3, and RASA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH2B3 grouped by Regulation of modification of synaptic structure-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SH2B3 →	-2.576	-1.002	.005	.009	3	5
PANCREAS	SOCS3 →	-1.067	-0.946	.003	.006	2	6
SOFT_TISSUE	RASA3 →	-1.351	-0.665	<.001	.003	3	4
LARGE_INTESTINE	CNNM2 →	+0.830	+0.910	.004	<.001	3	4
CNS	FIBCD1 →	-1.589	-1.060	.008	.001	3	4
BLOOD_Leukemia	TLR4 →	-1.735	-0.660	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH2B3 by Regulation of modification of synaptic structure activity — SOFT_TISSUE

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