Regulation of connective tissue replacement

Across TCGA patient cohorts, RNA activity of the Regulation of connective tissue replacement pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT6P3, DPT, and SH3BP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of connective tissue replacement activity versus CCT6P3 in LUAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CCT6P3 →	+0.362	+0.108	.005	.006	3	3
BRCA	DPT →	+0.905	+0.410	.007	.006	3	3
OV	SH3BP5 →	+0.532	+0.619	.005	.002	2	4
BRCA	CLEC5A →	+0.821	+0.524	<.001	<.001	3	3
COAD	FAM184A →	+0.311	+0.861	.001	.002	3	2
COAD	RRAS →	+0.343	+0.550	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905203 vs CCT6P3 — LUAD

Explore this scatter interactively →