Regulation of connective tissue replacement

Across TCGA cell cohorts, RNA activity of the Regulation of connective tissue replacement pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PFN2, and RBMX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of connective tissue replacement activity versus PLA2G4A in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLA2G4A →	-1.644	-0.646	<.001	.001	3	4
BLOOD_Leukemia	PFN2 →	+2.258	+0.943	.001	.001	3	4
BLOOD_Leukemia	RBMX →	+0.585	+1.002	.004	<.001	3	4
BLOOD_Leukemia	ZNF444 →	+0.827	+0.958	.002	.001	3	4
BLOOD_Leukemia	THEMIS2 →	-2.152	-0.862	<.001	<.001	3	3
CNS	RPRD1A →	+0.618	+0.506	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905203 vs PLA2G4A — BLOOD_Leukemia

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