Positive regulation of double-strand break repair via homologous recombination

Across TCGA patient cohorts, RNA activity of the Positive regulation of double-strand break repair via homologous recombination pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETDB1_S1066, SMARCC2, and SLC12A4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of double-strand break repair via homologous recombination activity versus SETDB1_S1066 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SETDB1_S1066 →	+0.544	+0.028	<.001	.002	3	6
LSCC	SMARCC2 →	+0.208	+0.039	<.001	<.001	3	6
GBM	SLC12A4 →	-0.328	-0.046	.001	<.001	3	6
HNSC	DSN1 →	+0.263	+0.064	.005	.008	3	6
HNSC	ITPRID2_S759 →	-1.055	-0.072	.001	.003	3	6
LUAD	NASP →	+0.352	+0.039	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905168 vs SETDB1_S1066 — LSCC

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