Lysosomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Lysosomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPAR6, DESI2, and MRPL9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPAR6 grouped by Lysosomal protein catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LPAR6 →	+1.688	+1.002	.005	.007	3	3
OVARY	DESI2 →	-0.768	-0.909	.001	.008	3	3
BREAST	MRPL9 →	-0.536	-0.624	.002	.003	3	3
OVARY	ZNF496 →	-0.846	-1.221	<.001	<.001	3	3
OVARY	CIBAR1 →	-0.958	-0.754	.002	.008	3	3
OVARY	SDAD1 →	-0.599	-1.127	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPAR6 by Lysosomal protein catabolic process activity — KIDNEY

Explore this box plot interactively →