Lysosomal protein catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Lysosomal protein catabolic process pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Lysosomal protein catabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UCS, show the opposite pattern, with higher activity associated with better survival.

LUAD, THCA, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.816	0.633	.005	46	view →
THCA	OS	Median	II,III,IV	0.957	0.993	.003	31	view →
UCS	DFS	Tertile	IV	0.860	0.239	.024	30	view →
BLCA	OS	Quartile	III,IV	0.728	0.367	.014	20	view →
TGCT	DFS	Tertile	All	0.980	0.735	<.001	18	view →
MESO	OS	Tertile	IV	0.156	0.719	.001	18	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	17	view →
KIRC	DFS	Median	III,IV	0.540	0.710	.010	17	view →
KIRP	DFS	Median	All	0.975	0.798	.007	16	view →
READ	OS	Median	II,III,IV	0.791	0.488	.007	13	view →
SKCM	DFS	Median	All	0.704	0.569	.009	12	view →
LUSC	OS	Tertile	III,IV	0.294	0.790	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:1905146–LUAD (OS)

Open the LUAD breakdown →