Lysosomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Lysosomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6AP1, FRMD6, and BCAP31, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal protein catabolic process activity versus ATP6AP1 in LARGE_INTESTINE (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP6AP1 →	+0.917	+1.077	.008	.002	3	5
BLOOD_Lymphoma	FRMD6 →	+1.567	+0.937	.002	.002	3	4
LARGE_INTESTINE	BCAP31 →	+0.719	+0.611	.001	.005	3	4
OVARY	GBP2 →	+1.756	+0.627	.004	.009	3	3
OVARY	KYAT1 →	-1.362	-1.214	.009	.001	3	3
SKIN	FSCN3 →	+0.202	+0.221	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905146 vs ATP6AP1 — LARGE_INTESTINE

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