Negative regulation of vascular associated smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC2, NFATC1, and NLRP3, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular associated smooth muscle cell differentiation activity versus NFATC2 in TGCT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	NFATC2 →	+1.125	+0.043	<.001	<.001	2	28
PCPG	NFATC1 →	+1.041	+0.060	<.001	<.001	3	27
LGG	NLRP3 →	+0.819	+0.050	<.001	<.001	3	26
DLBC	PDGFB →	+1.355	+0.081	<.001	<.001	3	26
LGG	LILRB1 →	+0.928	+0.048	<.001	<.001	3	26
PCPG	CD93 →	+1.414	+0.048	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905064 vs NFATC2 — TGCT

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