Regulation of vascular associated smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARM1, GTF2H1, and LRATD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARM1 grouped by Regulation of vascular associated smooth muscle cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PARM1 →	-2.453	-0.299	<.001	<.001	3	5
PANCREAS	GTF2H1 →	+0.853	+0.426	.002	<.001	3	4
LUNG_NSCLC_LUSC	LRATD1 →	-1.885	-0.297	.008	.009	3	4
LARGE_INTESTINE	E2F1 →	+0.808	+0.209	<.001	<.001	3	4
LARGE_INTESTINE	PLEKHH1 →	-1.542	-0.215	.001	.007	3	4
SOFT_TISSUE	XPC →	-1.314	-1.239	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARM1 by Regulation of vascular associated smooth muscle cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →