Negative regulation of metallopeptidase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of metallopeptidase activity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMG8, EXOSC5, and PP2D1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMG8 grouped by Negative regulation of metallopeptidase activity-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMG8 →	+1.252	+1.499	.001	<.001	3	5
BLOOD_Myeloma	EXOSC5 →	+0.945	+1.818	.008	<.001	3	4
BLOOD_Leukemia	PP2D1 →	-0.140	-0.982	<.001	.002	3	3
CNS	PIANP →	-1.247	-1.064	.001	.001	3	3
CNS	NOSTRIN →	-0.584	-0.946	<.001	.003	3	3
CNS	RFNG →	-0.608	-0.950	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMG8 by Negative regulation of metallopeptidase activity activity — BREAST

Explore this box plot interactively →