Negative regulation of metallopeptidase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of metallopeptidase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OBSCN, RAC1, and TLN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OBSCN grouped by Negative regulation of metallopeptidase activity-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OBSCN →	+0.171	+0.278	.002	.009	3	6
OVARY	RAC1 →	+0.392	+0.276	.001	.002	2	7
LIVER	TLN1 →	+0.532	+0.456	<.001	<.001	3	6
OESOPHAGUS	TAOK1 →	-0.241	-0.519	.004	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	NCR2 →	-0.278	-0.429	.004	.006	3	5
LIVER	RAG2 →	+0.484	+0.478	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OBSCN by Negative regulation of metallopeptidase activity activity — STOMACH

Explore this box plot interactively →