Negative regulation of metallopeptidase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of metallopeptidase activity pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are CRT0105950, AZD4547, and BIBF-1120, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRT0105950 grouped by Negative regulation of metallopeptidase activity-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CRT0105950 →	-0.463	-0.814	.017	.002	3	2
CNS	AZD4547 →	-1.710	-0.814	<.001	.002	3	2
CNS	BIBF-1120 →	-1.273	-0.814	.022	.002	3	2
CNS	Lestaurtinib →	-0.389	-0.814	.034	.002	3	1
CNS	CRT0105446 →	-0.473	-0.814	.048	.002	3	1
CNS	FS112 →	-0.250	-0.814	.020	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRT0105950 by Negative regulation of metallopeptidase activity activity — CNS

Explore this box plot interactively →