Regulation of metallopeptidase activity

Across TCGA cell cohorts, RNA activity of the Regulation of metallopeptidase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC1, TLN1, and TSSC4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC1 grouped by Regulation of metallopeptidase activity-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAC1 →	+0.420	+0.214	.001	<.001	3	7
LIVER	TLN1 →	+0.532	+0.184	<.001	.003	3	7
BLOOD_Lymphoma	TSSC4 →	+0.486	+0.326	.004	.003	3	5
UPPER_AERODIGESTIVE_TRACT	EDIL3 →	-0.207	-0.313	.004	.009	3	5
LUNG_NSCLC_LUSC	ITGAV →	+0.786	+0.161	.002	.003	2	6
BLOOD_Lymphoma	MRPL38 →	-0.437	-0.355	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC1 by Regulation of metallopeptidase activity activity — LIVER

Explore this box plot interactively →