Regulation of membrane repolarization during cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Regulation of membrane repolarization during cardiac muscle cell action potential pathway is significantly associated with the drug response of multiple features, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AMG-319, ZL049, and Dabrafenib, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMG-319 grouped by Regulation of membrane repolarization during cardiac muscle cell action potential-low versus -high activity in OVARY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AMG-319 →	+0.631	+1.248	.003	.010	3	5
OESOPHAGUS	ZL049 →	-0.416	-0.969	.033	.005	3	5
LARGE_INTESTINE	Dabrafenib →	-1.441	-1.099	.003	.030	3	5
STOMACH	630600 →	-0.887	-1.449	.021	.009	3	5
SKIN	eEF2K Inhibitor →	+0.141	+1.136	.015	.014	3	4
STOMACH	N23918-95-7 →	-0.434	-1.440	.040	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMG-319 by Regulation of membrane repolarization during cardiac muscle cell action potential activity — OVARY

Explore this box plot interactively →