Q-omics provides the ZL049 response profile across cancer cell-line models in the CCLE and GDSC pharmacogenomic screens. ZL049, an investigational agent, shows drug-response associations across 11 molecular data types, most extensively with CRISPR-dependency features, with the highest sampling consensus in CNS. CNS shows the largest number of associated molecular features, while functional-dependency data highlight CNS as a cancer context with signals that can be tested experimentally.
Each association is evaluated using two consensus scores. Sampling consensus shows how consistently a biomarker separates sensitive and resistant cell lines across repeated analysis settings. Lineage consensus shows how widely the same biomarker–response association appears across cancer lineages, distinguishing broadly shared signals from lineage-specific ones.
Cross-omics associations
This table summarizes molecular features associated with ZL049 sensitivity in cancer cell lines. Drug sensitivity data from CCLE and GDSC were compared with RNA expression, mutation, CRISPR, and shRNA dependency data. The Strength column shows the number of significant associated features for each molecular layer, and the Lineage column indicates the cancer lineage where the largest associated feature set is observed. The response to ZL049 is most broadly linked to CRISPR-dependency features, especially in CNS. CRISPR and shRNA dependency results also highlight experimentally testable signals in CNS.