Regulation of membrane repolarization during ventricular cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Regulation of membrane repolarization during ventricular cardiac muscle cell action potential pathway is significantly associated with the drug response of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Dabrafenib, 630600, and AMG-319, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Dabrafenib grouped by Regulation of membrane repolarization during ventricular cardiac muscle cell action potential-low versus -high activity in LARGE_INTESTINE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Dabrafenib →	-1.441	-1.099	.003	.030	3	5
STOMACH	630600 →	-0.887	-1.449	.021	.009	3	5
OVARY	AMG-319 →	+0.631	+1.248	.003	.010	3	5
OESOPHAGUS	ZL049 →	-0.416	-0.969	.033	.005	3	5
LARGE_INTESTINE	Refametinib →	-0.742	-1.092	.027	.043	3	4
BREAST	IAP_5620 →	-1.168	-0.784	.024	.041	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dabrafenib by Regulation of membrane repolarization during ventricular cardiac muscle cell action potential activity — LARGE_INTESTINE

Explore this box plot interactively →