Regulation of leukocyte adhesion to vascular endothelial cell

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP57, PAK5, and SUSD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP57 grouped by Regulation of leukocyte adhesion to vascular endothelial cell-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFAP57 →	-0.179	-0.150	.004	<.001	3	5
SKIN	PAK5 →	+0.194	+0.140	.001	<.001	3	5
SOFT_TISSUE	SUSD5 →	-0.270	-0.138	.003	<.001	3	4
LUNG_NSCLC_LUAD	LRRC4C →	+0.113	+0.096	<.001	.001	3	4
PANCREAS	RBM14-RBM4 →	+0.197	+0.122	.001	.004	2	4
PANCREAS	POU1F1 →	+0.137	+0.162	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP57 by Regulation of leukocyte adhesion to vascular endothelial cell activity — LARGE_INTESTINE

Explore this box plot interactively →