Brush border assembly

Across TCGA patient cohorts, RNA activity of the Brush border assembly pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLDC2, ANKS4B, and SMIM24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brush border assembly activity versus TLDC2 in PDAC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TLDC2 →	+0.621	+0.886	<.001	.002	3	4
PDAC	ANKS4B →	+1.370	+0.920	<.001	<.001	3	4
CCRCC	SMIM24 →	+1.355	+0.723	<.001	<.001	3	4
CCRCC	CYP3A5 →	+1.204	+0.852	<.001	<.001	3	4
CCRCC	HHLA2 →	+1.988	+0.980	<.001	<.001	3	4
CCRCC	SH3BGRL2 →	+0.787	+0.734	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904970 vs TLDC2 — PDAC

Explore this scatter interactively →