Brush border assembly

Across TCGA pan-cancer cohorts, RNA activity of the Brush border assembly pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Brush border assembly pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and LGG, show the opposite pattern, with higher activity associated with better survival.

CESC, LGG, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.866	0.591	.003	54	view →
LGG	OS	Median	All	0.872	0.752	<.001	50	view →
KIRC	OS	Tertile	All	0.714	0.559	<.001	48	view →
UVM	OS	Median	II,III,IV	0.460	0.771	.005	35	view →
READ	DFS	Median	III,IV	0.874	0.459	.005	27	view →
SCLC	OS	Quartile	All	0.780	0.558	.014	25	view →
OV	DFS	Tertile	IV	0.643	0.321	.006	18	view →
ESCA	OS	Tertile	All	0.489	1.000	.008	18	view →
PCPG	DFS	Quartile	All	0.304	0.824	.003	15	view →
BRCA	DFS	Quartile	II,III,IV	0.913	0.843	.007	15	view →
LIHC	OS	Median	All	0.780	0.634	.005	13	view →
THYM	DFS	Median	All	0.973	0.834	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:1904970–CESC (DFS)

Open the CESC breakdown →