Regulation of midbrain dopaminergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of midbrain dopaminergic neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP1, SFRP2, and C1S, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of midbrain dopaminergic neuron differentiation activity versus SFRP1 in BRCA (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SFRP1 →	+0.822	+0.055	<.001	<.001	3	6
COAD	SFRP2 →	+1.584	+0.103	<.001	<.001	3	5
CCRCC	C1S →	+0.467	+0.121	<.001	<.001	3	5
OV	ESRP2_S573 →	-0.451	-0.104	<.001	<.001	3	5
OV	NID1 →	+0.321	+0.088	.002	<.001	3	5
CCRCC	BAG2 →	+0.556	+0.100	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904956 vs SFRP1 — BRCA

Explore this scatter interactively →