Regulation of midbrain dopaminergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of midbrain dopaminergic neuron differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, DCTN2, and DUSP29, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Regulation of midbrain dopaminergic neuron differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TEAD1 →	+0.458	+1.090	.009	.001	3	6
CNS	DCTN2 →	+0.275	+2.227	.006	<.001	3	4
OVARY	DUSP29 →	-0.189	-1.329	.003	.001	3	4
LUNG_SCLC	NCKAP1 →	+0.273	+1.503	<.001	<.001	3	4
OESOPHAGUS	RER1 →	-0.224	-0.472	.002	<.001	3	4
CNS	AAMP →	-0.305	-1.229	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Regulation of midbrain dopaminergic neuron differentiation activity — CNS

Explore this box plot interactively →