Midbrain dopaminergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Midbrain dopaminergic neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP2, SERPINF1, and C1R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain dopaminergic neuron differentiation activity versus SFRP2 in OV (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SFRP2 →	+1.420	+0.087	<.001	<.001	3	9
BRCA	SERPINF1 →	+0.897	+0.054	<.001	<.001	3	8
OV	C1R →	+0.628	+0.072	<.001	<.001	3	8
OV	C1S →	+0.580	+0.081	<.001	<.001	3	8
OV	CAVIN3_S62 →	+0.688	+0.085	.002	.001	3	8
GBM	COL1A1 →	+0.925	+0.101	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904948 vs SFRP2 — OV

Explore this scatter interactively →