Midbrain dopaminergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Midbrain dopaminergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM12, SEC23A, and COL10A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain dopaminergic neuron differentiation activity versus ADAM12 in LUAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADAM12 →	+0.864	+0.141	.002	.001	3	5
PDAC	SEC23A →	+0.347	+0.211	.002	<.001	3	5
COAD	COL10A1 →	+1.244	+0.259	.001	<.001	3	5
LSCC	FRMD6 →	+0.895	+0.201	<.001	.001	3	5
LUAD	GJA1 →	+0.803	+0.116	<.001	.003	3	4
LSCC	TLCD2 →	+0.612	+0.209	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904948 vs ADAM12 — LUAD

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