Midbrain dopaminergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Midbrain dopaminergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA8, CLCN5, and TINAGL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain dopaminergic neuron differentiation activity versus ANXA8 in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ANXA8 →	+3.677	+0.308	<.001	<.001	3	6
LIVER	CLCN5 →	-1.874	-0.343	.001	.004	3	6
LUNG_NSCLC_LUAD	TINAGL1 →	+2.292	+0.321	<.001	.002	3	5
BREAST	NDUFC1 →	-1.073	-0.191	<.001	.007	2	6
LIVER	NME1 →	-1.394	-0.343	.003	.004	3	5
LUNG_NSCLC_LUSC	BLCAP →	+1.802	+0.210	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904948 vs ANXA8 — PANCREAS

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