Midbrain dopaminergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Midbrain dopaminergic neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNNB1, CTNND1, and CTNNA1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain dopaminergic neuron differentiation activity versus CTNNB1 in STOMACH (Pearson r = 0.89).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CTNNB1 →	+2.585	+0.406	<.001	<.001	3	12
PANCREAS	CTNND1 →	+2.276	+0.439	<.001	<.001	3	12
PANCREAS	CTNNA1 →	+2.721	+0.466	<.001	<.001	3	11
OVARY	CSNK1D →	-1.406	-0.381	.006	.002	3	10
PANCREAS	CTNNA2 →	+2.547	+0.444	<.001	<.001	3	9
OVARY	UBAP2L →	-1.282	-0.300	.007	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904948 vs CTNNB1 — STOMACH

Explore this scatter interactively →