Positive regulation of endothelial cell-matrix adhesion via fibronectin

Across TCGA patient cohorts, RNA activity of the Positive regulation of endothelial cell-matrix adhesion via fibronectin pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUSD6, TACC3, and ITGAV, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell-matrix adhesion via fibronectin activity versus SUSD6 in LUAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SUSD6 →	+0.369	+0.277	<.001	.006	3	3
GBM	TACC3 →	-0.497	-0.459	.005	.001	3	3
GBM	ITGAV →	+0.613	+0.534	<.001	.003	3	3
GBM	COL8A1 →	+1.150	+0.487	<.001	<.001	3	3
OV	EEF2K →	+0.838	+0.555	.002	.004	3	3
LUAD	TSC22D1-AS1 →	+0.287	+0.338	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904906 vs SUSD6 — LUAD

Explore this scatter interactively →