Positive regulation of endothelial cell-matrix adhesion via fibronectin

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell-matrix adhesion via fibronectin pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLT8D2, NBPF20, and CCDC181, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell-matrix adhesion via fibronectin activity versus GLT8D2 in PANCREAS (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GLT8D2 →	-0.327	-0.454	.009	.007	3	4
SKIN	NBPF20 →	-0.690	-1.493	<.001	.001	3	3
LUNG_SCLC	CCDC181 →	-2.488	-2.168	.003	<.001	3	3
LARGE_INTESTINE	PRKCE →	+0.847	+1.127	<.001	<.001	3	3
LARGE_INTESTINE	IKBKG →	+0.949	+1.116	.002	.001	3	3
SKIN	MAD2L2 →	-0.707	-1.417	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904906 vs GLT8D2 — PANCREAS

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