Positive regulation of receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor signaling pathway via STAT pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ELMO1, RCSD1, and WIPF1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor signaling pathway via STAT activity versus ELMO1 in OV (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ELMO1 →	+0.455	+0.053	<.001	<.001	3	9
LSCC	RCSD1 →	+0.459	+0.078	<.001	<.001	3	9
OV	WIPF1 →	+0.492	+0.066	<.001	<.001	3	9
OV	DOCK10 →	+0.523	+0.085	<.001	<.001	3	9
GBM	FMNL1 →	+0.569	+0.077	<.001	<.001	3	9
UCEC	FNBP1 →	+0.601	+0.093	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904894 vs ELMO1 — OV

Explore this scatter interactively →