Positive regulation of receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR52I1, CCNA2, and ACSM4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor signaling pathway via STAT activity versus OR52I1 in CCRCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OR52I1 →	+0.200	+0.188	<.001	<.001	3	3
UCEC	CCNA2 →	+0.966	+0.542	<.001	.001	3	3
COAD	ACSM4 →	+0.242	+0.336	.003	.002	3	3
LUAD	IFT46 →	-0.376	-0.332	.002	.002	3	3
BRCA	RN7SKP297 →	+0.199	+0.620	.005	.005	3	3
LSCC	FBXO5 →	+0.503	+0.260	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904894 vs OR52I1 — CCRCC

Explore this scatter interactively →