Positive regulation of receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor signaling pathway via STAT pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRNP70_S417, BICD1, and C19orf54, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor signaling pathway via STAT activity versus SNRNP70_S417 in PDAC (Pearson r = -0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SNRNP70_S417 →	-0.744	-0.201	.001	.003	3	2
PDAC	BICD1 →	-0.318	-0.354	<.001	.002	3	2
PDAC	C19orf54 →	+0.812	+0.494	<.001	<.001	3	2
PDAC	CDCA2_S400 →	+0.465	+0.221	.002	<.001	3	2
GBM	CEND1_S87 →	+0.673	+0.712	<.001	<.001	3	2
UCEC	CLASP1_S636 →	+0.856	+0.712	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904894 vs SNRNP70_S417 — PDAC

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