Positive regulation of receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OCIAD2, TMEM184A, and STEAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor signaling pathway via STAT activity versus OCIAD2 in LUNG_NSCLC_LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OCIAD2 →	+1.647	+0.534	<.001	.003	3	5
LUNG_SCLC	TMEM184A →	+2.204	+0.927	.006	.004	3	5
PANCREAS	STEAP4 →	+1.987	+0.400	.007	.003	3	5
PANCREAS	ALPK3 →	+1.809	+0.433	.003	.003	3	5
PANCREAS	DUSP10 →	+1.985	+0.381	<.001	<.001	3	5
PANCREAS	MAL2 →	+4.778	+0.406	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904894 vs OCIAD2 — LUNG_NSCLC_LUAD

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