Negative regulation of receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLX1, TTC7B, and DUSP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor signaling pathway via STAT activity versus DLX1 in PANCREAS (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DLX1 →	+1.488	+0.255	.002	.003	3	5
STOMACH	TTC7B →	+2.869	+1.434	<.001	<.001	3	5
BONE	DUSP5 →	+1.657	+0.491	.004	.006	3	5
STOMACH	AFAP1L1 →	+1.524	+1.128	.009	.006	3	5
UPPER_AERODIGESTIVE_TRACT	NME7 →	+1.188	+0.432	.003	.002	3	5
CNS	STT3B →	-0.343	-0.234	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904893 vs DLX1 — PANCREAS

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