Regulation of receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Regulation of receptor signaling pathway via STAT pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2, APBB1IP, and ARHGAP25, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor signaling pathway via STAT activity versus THEMIS2 in GBM (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	THEMIS2 →	+0.415	+0.049	<.001	<.001	3	9
UCEC	APBB1IP →	+0.554	+0.066	<.001	.002	3	9
UCEC	ARHGAP25 →	+0.605	+0.069	<.001	<.001	3	9
BRCA	PTPRC →	+0.588	+0.030	<.001	<.001	3	9
OV	WIPF1 →	+0.446	+0.042	.001	.003	3	9
OV	C1S →	+0.722	+0.046	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904892 vs THEMIS2 — GBM

Explore this scatter interactively →