Regulation of receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNA2, CCR1, and CENPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor signaling pathway via STAT activity versus KPNA2 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KPNA2 →	+0.726	+0.649	<.001	<.001	3	5
HNSC	CCR1 →	+0.702	+0.233	.008	.003	3	5
BRCA	CENPA →	+1.188	+0.611	<.001	<.001	3	4
BRCA	CEP55 →	+0.955	+0.344	<.001	.001	3	4
BRCA	NUF2 →	+0.956	+0.377	<.001	<.001	3	4
UCEC	MTFR2 →	+0.658	+0.439	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904892 vs KPNA2 — BRCA

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